First year of THROMBUS project in brief

The first year of THROMBUS project is ending, it is time to make a summary of the main scientific points:

Cerebral aneurysms are undesired local deformations of the wall of a brain vessel whose rupture can be lethal. The natural repair of an aneurysm is through a thrombosis process that fills in the cavity; eventually leading to the remodelling of the wall vessel. The objective of THROMBUS is the fundamental understanding of the thrombosis mechanisms in intracranial aneurysms.

To make progress in this domain, the TRHROMBUS project will implement models to provide a realistic numerical simulation of the genesis and of the growth of the thrombus by taking in consideration medical imaging, biological data and medical data. In consequence, the architecture of the project is based on the triptych ‘In vivo – In vitro – In silico.

 

Segmentation of an Intracranial Aneurysm 

Virtual Blood Flow

 

After one year passed, the consortium works on the different bricks of the project and relevant results arise.

On the computer simulation side, an open source macroscopic model has been developed, that run on massively parallel machines, if needed. It includes the blood flow and a basic model for the growth of a thrombus and can be applied to patient specific geometries. Another microscopic numerical model has also been developed in order to better understand the detailed transport of blood particles in localized region of space and time. Biological experiments and clinical observations are used to validate and calibrate these models. Indeed, the measures obtained during this first year, on whole blood from volunteers, highlighted the major role of the shear rate and the interface composition on the platelets adhesion.

However, the project running, we know that the crucial point to understand the thrombosis phenomena is to strengthen focus our research on the analysis of the secretions of the endothelium when submitted to wall shear stresses, and its ability to catalyse the aggregation of platelets process to form the thrombus.

In order to reinforce the consortium in this direction two new collaborations have been initialized, one with the team IRRAS (Individual Risk Rupture ASsessment of Intracranial Aneurysm) team of the CHU of Montpellier, to more learn more on the mechanical properties of the wall of the aneurysms, and a MIT team, member of the Laboratory for Systems Biology to learn more on the behaviour of the endothelium within an aneurysm.
 

The second year of THROMBUS will be crucial,

in the sense that the success of the project will be conditioned in major part, by our ability to implement in our codes of numerical simulation the complex biological processes and biophysical data leading to a realistic modelling of the thrombosis.

 

Virtual Deployment of a Stent