The third Technical Review Meeting validating the third period and the entire project THROMBUS took place in Brussels on the 26th May 2014.
The results generated are very good and have significantly advanced state-of-the-art in modelling intra-aneurysmal thrombosis and improving our understanding of the role of platelets, red blood cells, endothelium, hemodynamic forces and the complex interactions involved in intra-aneurysmal thrombosis.
Endovascular devices and procedures have substantially evolved to be one of the principal alternatives to treat intracranial aneurysms.
Thanks to advances in technology, improvements on imaging and a growing market on minimally invasive surgery devices, nowadays medical practitioners have a wider set of treatment options to make an objective decision nearly adapted to the specific condition of the patient.
One of the main challenges of Thrombus is to perform the modeling of a flow diverter armed with 48 struts.
The main research topic leads to the modelling of the deployment of a virtual flow diverter within a parent vessel allowing the study of the effect on the blood flow within the cavity of an aneurysm.
As a result of the collaborations within the THROMBUS project, a patent has been filed in March 2013.
It concerns a test bench allowing to reproduce complex pulsed flow in silicone aneurysms designed from three-dimensional images of patients' aneurysms and placed in a scanner.
A quantitative model of thrombosis in intracranial aneurysms
The objective of THROMBUS project is to conceptualize a sophisticated biological model of spontaneous or stent-induced thrombosis within Intracranial Aneurysms. In consequence, the crucial concerns are the building of a realistic scenario of the thrombosis and its associated modelling, the implementation of the code of numerical simulation based on the Lattice Boltzmann method.
The first year of THROMBUS project is ending, it is time to make a summary of the main scientific points:
Cerebral aneurysms are undesired local deformations of the wall of a brain vessel whose rupture can be lethal. The natural repair of an aneurysm is through a thrombosis process that fills in the cavity; eventually leading to the remodelling of the wall vessel. The objective of THROMBUS is the fundamental understanding of the thrombosis mechanisms in intracranial aneurysms.
